Dmd #14340 Induction of Drug-metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Car and Nrf2
نویسندگان
چکیده
Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (C.D.F., L.M.A., N.J.C.), Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (J.M.M., C.D.K.), Department of Discovery Toxicology, Bristol-Myers Squibb, Princeton, New Jersey (D.M.N, L.D.L.), Department of Biomedical Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Rhode Island (A.L.S) DMD Fast Forward. Published on March 12, 2007 as doi:10.1124/dmd.106.014340
منابع مشابه
Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways.
Drug-metabolizing enzymes and transporters are key factors that affect disposition of xenobiotics. Phase I enzyme induction by classes of microsomal enzyme inducers occurs via activation of transcription factors such as aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), peroxisome proliferator-activated receptor alpha (PPARalpha), and nuclear fac...
متن کاملDifferent activation patterns of rat xenobiotic metabolism genes by two constituents of garlic.
Diallyl sulfide (DAS) and diallyl disulfide (DADS) are natural components that could account for the anticarcinogenic properties of garlic, at least in part, through the activation of xenobiotic detoxifying metabolism. The aim of this work was to describe the effect of DAS and DADS on xenobiotic-related gene expressions and to study molecular mechanisms relaying DAS effect. We describe the diff...
متن کاملGarlic Extract Diallyl Sulfide (DAS) Activates Nuclear Receptor CAR to Induce the Sult1e1 Gene in Mouse Liver
Constituent chemicals in garlic extract are known to induce phase I and phase II enzymes in rodent livers. Here we have utilized Car(+/+) and Car(-/-) mice to demonstrate that the nuclear xenobiotic receptor CAR regulated the induction of the estrogen sulfotransferase Sult1e1 gene by diallyl sulfide (DAS) treatment in mouse liver. DAS treatment caused CAR accumulation in the nucleus, resulting ...
متن کاملDifferential effects of garlic oil and its three major organosulfur components on the hepatic detoxification system in rats.
The objective of this study was to compare the modulatory effect of garlic oil and its three organosulfur compounds, diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS), on rat hepatic detoxification enzyme activity, and protein and mRNA expression. Rats were orally administered garlic oil (80 or 200 mg/kg bw), DAS (20 or 80 mg/kg bw), DADS (80 mg/kg bw), or DATS (70 ...
متن کاملThe Nrf2 activator oltipraz also activates the constitutive androstane receptor.
Oltipraz (OPZ) is a well known inducer of NAD(P)H:quinone oxidoreductase (NQO1) along with other enzymes that comprise the nuclear factor E2-related factor 2 (Nrf2) battery of detoxification genes. However, OPZ treatment also induces expression of CYP2B, a gene regulated by the constitutive androstane receptor (CAR). Therefore, this study was designed to determine whether OPZ induces gene expre...
متن کامل